| Autor: |
B, Hsieh, M D, Schrenzel, T, Mulvania, H D, Lepper, L, DiMolfetto-Landon, D A, Ferrick |
| Rok vydání: |
1996 |
| Předmět: |
|
| Zdroj: |
Journal of immunology (Baltimore, Md. : 1950). 156(1) |
| ISSN: |
0022-1767 |
| Popis: |
Differential cytokine production by gamma delta+ T cells influences Th1 and Th2 responses. Here, we describe the in vivo kinetics of peritoneal and splenic gamma delta+, CD4+, and CD8+ T cell cytokine responses during primary and secondary Listeria infections. The data show differences in the kinetics of IFN-gamma-producing alpha beta+ splenocytes consistent with immunologic memory. Most noteworthy, however, was the elevated production of IL-10 by splenic gamma delta+ T cells in the red pulp and marginal zones that coincided with maximal IFN-gamma production and with a decrease in inflammation and tissue damage. This result implies a role for gamma delta+ T cells in the control of Th1 responses. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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