| Autor: |
T I, Gudz', E N, Gorodovikova, V G, Boushev, I G, Pandelova, E N, Goncharenko |
| Rok vydání: |
1987 |
| Předmět: |
|
| Zdroj: |
Radiobiologiia. 27(1) |
| ISSN: |
0033-8192 |
| Popis: |
A study was made of generation of superoxide anion-radical (O2-) by cytochrome P-450 in a microsomal membrane of rat liver. Using spectrophotometry (by oxidation of adrenaline to adrenochrome) and ESR (with a spin-trap, tiron) the authors showed the ability of O2- generation by P-450 through decomposition of organic peroxides. During the first 24 h following irradiation of rats with doses of 7 and 10 Gy, the generation of O2- by cytochrome P-450 of rat liver microsomes was increased. Mechanisms of the postirradiation modification of O2- generation rate are discussed. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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