| Autor: |
M, Walzl, B, Walzl, G, Schied, H, Lechner |
| Jazyk: |
němčina |
| Rok vydání: |
1993 |
| Předmět: |
|
| Zdroj: |
Wiener klinische Wochenschrift. 105(14) |
| ISSN: |
0043-5325 |
| Popis: |
Fibrinogen appears to play an important role in atherogenesis, whereby high levels of fibrinogen can lead to a disturbance of the haemorheologic pattern. To evaluate the association between fibrinogen and blood sedimentation rate (BSR) 40 patients suffering from cerebral multi-infarct disease underwent a single heparin-induced extracorporeal LDLfibrinogenprecipitation (HELP). Subsequently they were randomly assigned to two groups, either receiving sustained-release bezafibrate 400 mg daily (n = 21) or placebo (n = 19) over a period of eight weeks. HELP led to a statistically significant reduction of fibrinogen (p0.0001). At the end of the trial the difference between the bezafibrate group and the controls became significant (p0.05). The BSR strictly followed the course of fibrinogen, indicating a significant reduction after HELP (p0.0001 for both BSR values) and a difference between both groups at the end of the study (p0.05 and p0.03, respectively). The correlation between fibrinogen and BSR remained significant during the whole trial. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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