Bioactivation of thalidomide by a monkey liver fraction in a rat limb culture system

Autor:	T H, Shepard, K, Shiota
Rok vydání:	1983
Předmět:	Male Organ Culture Techniques Liver Pregnancy Animals Extremities Female Rats Inbred Strains Macaca nemestrina Biotransformation Rats Thalidomide
Zdroj:	Progress in clinical and biological research.
ISSN:	0361-7742
Popis:	The effect of thalidomide on a rat limb bud system has been studied in vitro. Thalidomide and adult monkey liver supernatants activated with cofactors for the mixed function monooxygenase system inhibited growth. Similar preparations from the rat did not inhibit growth. Planimetric measures of the surface area of limb buds were found to correlate closely with their protein contents. The ability to compare metabolizing systems from different mammals may be useful in extrapolating teratologic data between different species.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::7c93fb7ca55b73fd480b3ff219f6c5fa https://pubmed.ncbi.nlm.nih.gov/6828503 Zobrazit plný text záznamu