[Correlation between ATP bioluminescence tumor chemosensitivity assay and clinical response in ovarian cancer]
| Autor: | Hai-mei, Tian, Xiao-yan, Shi, Jun, Fu, Dong-yan, Chao, Kai, Zhang, Ling-ying, Wu, Jin-wan, Wang, Wei, Zhang |
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| Rok vydání: | 2005 |
| Předmět: |
Adult
Ovarian Neoplasms Paclitaxel Carcinoma Antineoplastic Agents Middle Aged Sensitivity and Specificity Adenosine Triphosphate Drug Resistance Neoplasm Predictive Value of Tests Antineoplastic Combined Chemotherapy Protocols Luminescent Measurements Humans Female Cisplatin Drug Screening Assays Antitumor Cyclophosphamide Aged |
| Zdroj: | Zhonghua zhong liu za zhi [Chinese journal of oncology]. 27(5) |
| ISSN: | 0253-3766 |
| Popis: | To determine the correlation between results of ATP bioluminescence tumor chemosensitivity assay (ATP-TCA) of human ovarian cancer specimens in vitro and clinical chemo-therapeutic responses of patients.Thirty-four freshly taken ovarian cancer specimens (28 cases) and ascites (6 cases) and 9 chemotherapeutic drugs were tested in vitro for cancer chemosensitivity by ATP-TCA.Among the 34 ovarian cancer cases, the efficacy of ATP-TCA is 94.0%, the sensitivity, the specificity, the positive and negative predicting values, and an overall predicting value in vitro and vivo were 90.0%, 91.7%, 94.7%, 84.6% and 90.6%, respectively.The results of ATP-TCA assay are correlated well with clinical treatment responses. The assay may be an important and useful method for individual-based chemotherapy of cancers. |
| Databáze: | OpenAIRE |
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