Mercury accumulations in brains from populations exposed to high and low dietary levels of methyl mercury. Concentration, chemical form and distribution of mercury in brain samples from autopsies
| Autor: | M B, Pedersen, J C, Hansen, G, Mulvad, H S, Pedersen, M, Gregersen, G, Danscher |
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| Rok vydání: | 1999 |
| Předmět: |
Adult
Aged 80 and over Brain Chemistry Cerebral Cortex Male Medulla Oblongata Chi-Square Distribution Mercury Compounds Denmark Greenland Age Factors Brain Environmental Exposure Middle Aged Hippocampus Immunohistochemistry Sampling Studies Statistics Nonparametric Cerebellum Humans Female Tissue Distribution Autopsy Aged |
| Zdroj: | International journal of circumpolar health. 58(2) |
| ISSN: | 1239-9736 |
| Popis: | Autopsy samples from 17 Greenlanders and 12 Danes were analysed for total and organic mercury by atomic absorption spectrophotometry, and for cellular localisation by autometallography. The concentration of total mercury in the Greenlanders (median: 174 micrograms Hg/kg wet weight brain tissue, range 59-4782, highest in cerebellum: 492) was found to be significantly higher than in the Danish group (3.7 micrograms Hg/kg w.w., range 1.2-11.8). Furthermore, the total concentration of mercury was positively correlated to age (rho = 0.56, p0.05), and the fraction of methyl mercury was negatively correlated to age (rho = -0.66, p0.01) among the Greenlanders. This suggests an age dependent accumulation of total mercury and a slow transformation of methyl mercury to inorganic mercury in the brain. The autometallographically demonstrable mercury was primarily located in glia cells. |
| Databáze: | OpenAIRE |
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