| Autor: |
Ourania, Batsi, Ioanna, Giannopoulou, Ioannis, Nesseris, Christos, Valavanis, Hariklia, Gakiopoulou, Efstratios S, Patsouris, Petroula, Arapandoni-Dadioti, Andreas C, Lazaris |
| Rok vydání: |
2014 |
| Předmět: |
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| Zdroj: |
Anticancer research. 34(7) |
| ISSN: |
1791-7530 |
| Popis: |
The aim of this study was to investigate the expression of CXC chemokine ligand-12 (CXCL12), CXC chemokine receptor 4 CXCR4 and of vascular endothelial growth factor receptor 3 (VEGFR3) in primary urothelial bladder carcinoma and their recurrence in relation to grade and pT status.Immunohistochemistry was applied to 67 primary tumor (PC) sections and their recurrenct tumors (RC).The expression of CXCL12 both in PC and in RC was positively associated with tumor grade (p0.0001 and p0.0001, respectively) and pT stage (p=0.001 and p=0.007, respectively). The expression of CXCR4 in both PC and RC was also positively related to grade (p=0.001 and p0.0001, respectively) and pT stage (p=0.008 and p=0.005, respectively). We compared the expression of CXCL12 and CXCR4 in PC related to RC and found that both were more intense in RC than in PC (p0.0001 and p0.0001, respectively). In PC and in RC there was no association between the expression of VEGFR3 with tumor grade and pT stage.CXCL12 and CXCR4 expression was related to adverse prognostic markers in urothelial bladder carcinoma through their association with grade and pT stage both in PC and RC. The CXCL12-CXCR4 axis may influence the expression of VEGFR3 in urothelial bladder carcinoma and promote tumor recurrence. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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