| Autor: |
Emir, Behluli, Nexhibe, Nuhii, Thomas, Liehr, Gazmend, Temaj |
| Rok vydání: |
2022 |
| Zdroj: |
Journal of mother and childReferences. |
| ISSN: |
2719-535X |
| Popis: |
Children with Down syndrome (DS) are at markedly increased risk for acute lymphoblastic leukaemia (ALL). DS is caused by trisomy of chromosome 21 affecting approximately 1 in 732 newborns in the USA. ALL is the most common cancer in children and constitutes approximately 25% of cancer diagnoses among children under the age of 15. Different protocols for treatment and management of paediatric ALL are available; however, DS children with ALL (DS-ALL) have increased risk of therapy-related toxicity compared to those without DS. Herein, we summarize the available literature on inherited predisposition for ALL, and possibilities for molecular therapy and treatment for DS-ALL patients. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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