Testosterone metabolism in benign and malignant breast lesions

Autor:	L I, Rose, R H, Underwood, M T, Dunning, G H, Williams, G S, Pinkus
Rok vydání:	1975
Předmět:	Adult Adolescent Histocytochemistry Androstenedione Breast Neoplasms Dihydrotestosterone Mastitis Adenocarcinoma In Vitro Techniques Middle Aged Pregnancy Methods Humans Female Testosterone Carbon Radioisotopes Adenofibroma Cells Cultured
Zdroj:	Cancer. 36(2)
ISSN:	0008-543X
Popis:	Tissues from a variety of breast lesions were incubated with 14C-testosterone (17beta-hydroxy-4-androsten-3-one). Conversion to 14C-5alpha-dihydrotestosterone (17beta-hydroxy-5alpha-androstan-3-one) and 14C-androstenedione (4-androsten-3,17-dione) was measured. Normal breast tissue showed formation of 14C-androstenedione but no formation of 14C-5alpha-dihydrotestosterone. Fibroadenomas showed a high degree of testosterone metabolism forming both 14C-androstenedione and 14C-5alpha-dihydrotestosterone. The adenocarcinomas of the breast, contrary to a previous report in the literature, showed no conversion to 14C-5alpha-dihydrotestosterone. The data suggest that formation of 5alpha-dihydrotestosterone is a predominant metabolic pathway in fibroadenoma.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::7bfd3df05f49259137239742e8813d2f https://pubmed.ncbi.nlm.nih.gov/1171721 Zobrazit plný text záznamu Plný text