Targeting IgE in Severe Atopic Dermatitis with a Combination of Immunoadsorption and Omalizumab
| Autor: | Alexander, Zink, Anna, Gensbaur, Michael, Zirbs, Florian, Seifert, Isabel Leon, Suarez, Vagkan, Mourantchanian, Stephan, Weidinger, Martin, Mempel, Johannes, Ring, Markus, Ollert |
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| Rok vydání: | 2015 |
| Předmět: |
Adult
Male Time Factors Remission Induction Pilot Projects Omalizumab Immunoglobulin E Middle Aged Combined Modality Therapy Severity of Illness Index Dermatitis Atopic Treatment Outcome Anti-Allergic Agents Blood Component Removal Disease Progression Humans Female Biomarkers Immunosorbent Techniques Aged |
| Zdroj: | Acta dermato-venereologica. 96(1) |
| ISSN: | 1651-2057 |
| Popis: | Patients with atopic dermatitis (AD) tend to have greatly elevated levels of serum immunoglobulin E (IgE). However, the role of IgE in the pathogenesis of AD is debated. This investigator-initiated open-label pilot study evaluates an anti-IgE-treatment approach by combining extracorporeal immunoadsorption and anti-IgE antibody omalizumab in 10 patients with severe, therapy-refractory AD. IgE levels decreased after immunoadsorption and decreased continuously in all patients during anti-IgE therapy. The reverse trend was observed during 6 months follow-up without treatment. In parallel with these observations, an improvement in AD was observed during the treatment period, with aggravation during follow-up. Further research is needed, based on the principle of reducing IgE levels in order to improve clinical symptoms, using a combination anti-IgE treatment approach, adjusted according to IgE levels. |
| Databáze: | OpenAIRE |
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