Distinct clonal origin of low-grade MALT-type and high-grade lesions of a multifocal gastric lymphoma

Autor:	A, Matolcsy, M, Nagy, N, Kisfaludy, G, Kelényi
Rok vydání:	1999
Předmět:	Gene Rearrangement Lymphoma B-Cell Base Sequence Lymphoma Non-Hodgkin Molecular Sequence Data Lymphoma B-Cell Marginal Zone Middle Aged Clone Cells Neoplasms Multiple Primary Stomach Neoplasms Sequence Homology Nucleic Acid Humans Female Amino Acid Sequence Immunoglobulin Heavy Chains
Zdroj:	Histopathology. 34(1)
ISSN:	0309-0167
Popis:	Low-grade mucosa-associated lymphoid tissue (MALT) lymphoma and high-grade B-cell non-Hodgkin's lymphoma (NHL) of the stomach may occur simultaneously. To determine the clonal relationship between these tumours, we compared the immunoglobulin heavy chain gene (IgH) rearrangements of low and high-grade components of a multifocal gastric NHL.The complementary determining region 3 (CDR3) of the IgH gene rearrangements were polymerase chain reaction (PCR) amplified, cloned and sequenced. The analysis of the CDR3 sequences rearranged by tumour cells of low-grade MALT and the high-grade NHL revealed different nucleic acid sequences.These findings suggest that low-grade MALT and high-grade B-cell components of multifocal gastric NHL may represent unrelated clones.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::7bd96a70d846c70e93fc7ed98573ba9f https://pubmed.ncbi.nlm.nih.gov/9934588 Zobrazit plný text záznamu Plný text ve formátu PDF