The Role of Toll-Like Receptors 2 and 4 in the Pathogenesis of Chronic Obstructive Pulmonary Disease

Autor:	Sidletskaya, Karolina, Vitkina, Tatyana, Denisenko, Yulia
Jazyk:	angličtina
Rok vydání:	2020
Předmět:	Inflammation Toll-Like Receptor 4 Pulmonary Disease Chronic Obstructive toll-like receptor 2 T-helper immune response Humans Review chronic obstructive pulmonary disease
Zdroj:	International Journal of Chronic Obstructive Pulmonary Disease
ISSN:	1178-2005 1176-9106
Popis:	Currently, chronic obstructive pulmonary disease (COPD) is one of the leading causes of morbidity and mortality worldwide. The determination of immune mechanisms of inflammation in the disease presents an important challenge for fundamental medical research. According to modern views, Toll-like receptors (TLRs), among which TLR2 and TLR4 play a key role, are one of the essential components of inflammatory process in COPD. This review focuses on following aspects: the role of TLR2 and TLR4 in the initiation of inflammatory process in COPD; the mechanisms of influence of various exogenous factors (cigarette smoke, suspended particulate matter, and bacteria) on the expression of TLR2 and TLR4; the contribution of these TLRs to the T-helper (Th) immune response development in COPD, in particular to the Th17 immune response, which contributes to the progression of the disease and therapeutic implications of TLR2 and TLR4 in COPD.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::7bd06b795483abe957cd219cbf27acaf http://europepmc.org/articles/PMC7320879 Zobrazit plný text záznamu