[Effect of levosimendan on B-type natriuretic peptide levels in patients with advanced heart failure: a meta-analysis]

Autor: Zhong-dong, Xu, Wei-xiong, He, Yi-fan, Zhao, Shu-xuan, Xia, Bo, He, Tao, Yang, De-xiong, Cao, Shu-ling, Peng, Jue, Li, Ming-hui, Cao
Rok vydání: 2009
Předmět:
Zdroj: Nan fang yi ke da xue xue bao = Journal of Southern Medical University. 29(10)
ISSN: 1673-4254
Popis: To conduct a meta-analysis of the effect of levosimendan on B-type natriuretic peptide (BNP) levels and evaluate the therapeutic effect of levosimendan on advanced heart failure.A meta-analysis was performed on the selected data to analyze the effect of levosimendan on BNP levels.Levosimendan decreased BNP by a mean of 337.66 [95%CI (-296.30, -379.02)] pg/ml 24 h after the administration, and by 259.92 [95%CI (-195.76, -324.08)] pg/ml at 48 h, and by 123.09 [95%CI(-53.32,-195.86)] pg/ml at 1 week. Levosimendan resulted in improvements of the cardiac function by about 29%, 22%, and 10% at 24 h, 48 h and 1 week after the administration.Levosimendan produces favorable effects on the cardiac functions and BNP levels.
Databáze: OpenAIRE