| Autor: |
Sarael, Alcauter-Solórzano, Erick H, Pasaye-Alcaraz, Patricia, Alvarado-Alanis, Rafael O, Fermín-Delgado, M Elisa, Alonso-Vilatela, Perla, Salgado-Lujambio, Fernando A, Barrios |
| Rok vydání: |
2010 |
| Předmět: |
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| Zdroj: |
Revista de neurologia. 51(4) |
| ISSN: |
1576-6578 |
| Popis: |
Huntington's disease is an hereditary autosomic-dominant neurodegenerative disorder, characterized by motor, cognitive and psychiatric symptoms.To quantify differences in N-acetylaspartate, creatine and choline in caudate nucleus, putamen and occipital cortex of patients with Huntington's disease, symptomatics and asymptomatics.Hydrogen magnetic resonance spectroscopy was performed with a 3 T scanner in 10 Huntington's disease gene-tested subjects, included in three groups: negative (control), positive symptomatics and positive asymptomatics. Data was quantified with LCModel and analyzed with ANOVA and Fisher tests.Symptomatic patients showed decreased creatine and N-acetylaspartate in the three regions, and decreased choline only in putamen (p0.05). Choline difference was found between symptomatics and asymptomatics in the caudate nucleus (p0.05).Results may reflect neuronal dysfunction and suggest that creatine and choline may serve as markers for Huntington's disease progression. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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