Susceptibility-Associated Genetic Variation in

Autor: Dong, Han, Jude N, Owiredu, Bridget M, Healy, Muqing, Li, Maryam, Labaf, Jocelyn S, Steinfeld, Susan, Patalano, Shuai, Gao, Mingyu, Liu, Jill A, Macoska, Kourosh, Zarringhalam, Kellee R, Siegfried, Xin, Yuan, Timothy R, Rebbeck, Changmeng, Cai
Rok vydání: 2020
Předmět:
Zdroj: Cancer research. 81(14)
ISSN: 1538-7445
Popis: Although American men of European ancestry represent the largest population of patients with prostate cancer, men of African ancestry are disproportionately affected by prostate cancer, with higher prevalence and worse outcomes. These racial disparities in prostate cancer are due to multiple factors, but variations in genomic susceptibility such as SNP may play an important role in determining cancer aggressiveness and treatment outcome. Using public databases, we have identified a prostate cancer susceptibility SNP at an intronic enhancer of the neural precursor expressed, developmentally downregulated 9 (
Databáze: OpenAIRE