Influence of the GPX1 gene polymorphism to aerobic capacity and efficiency of glutathione supplementation in athletes
| Autor: | A D, Lifanov, M N, Khadyeva, L Sh, Rakhmatullina, S V, Demenev, G F, Khamidullina, A M, Chekulaeva, E M, Sofronova |
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| Rok vydání: | 2014 |
| Předmět: |
Adult
Male Glutathione Peroxidase Heterozygote Genotype Proline Homozygote Gene Expression Glutathione Injections Intramuscular Polymorphism Single Nucleotide Antioxidants Oxygen Consumption Glutathione Peroxidase GPX1 Gene Frequency Athletes Leucine Case-Control Studies Physical Endurance Humans Female Alleles |
| Zdroj: | Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova. 100(2) |
| ISSN: | 0869-8139 |
| Popis: | The aim was to investigate compare genotype and allele frequencies of the GPX1 gene Pro198Leu polymorphism in 736 Russian athletes and 564 non-athletic controls. Echocardiography was performed by ultrasound scanner Nemio MX (Toshiba, Japan). Also, we investigated whether glutathione had antioxidant effects in runners. Runners of the experimental group 1 (16 persons) unlike the group 2 (16 persons) had been administered 600 mg of glutathione sodium intramuscularly after trainings daily, during 14 days. The best response to glutathione was presented by the GPX1 Pro allele. |
| Databáze: | OpenAIRE |
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