Autor: |
Chong, Han, Yang, He, Lifen, Chen, Jie, Wang, Song, Jiao, Xiangping, Xia, Gang, Li, Shengtao, Yao |
Rok vydání: |
2020 |
Předmět: |
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Zdroj: |
OncoTargets and therapy |
ISSN: |
1178-6930 |
Popis: |
Background This study was performed to explore the clinical and prognostic significance of APOB mRNA expression, DNA methylation and APOB mutation in patients with low-grade glioma (LGG). Methods Bioinformatic analysis was conducted using genomic, clinical and survival data from The Cancer Genome Atlas (TCGA) and Chinese Glioma Genome Atlas (CGGA) databases. Serum APOB protein levels were measured via immunoturbidimetry in 150 patients with LGG and 100 healthy controls from Hubei General Hospital. Results There was a negative association between the levels of APOB mRNA and DNA methylation (r=−0.355, P |
Databáze: |
OpenAIRE |
Externí odkaz: |
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