The Effect of Xylazine/Zoletil Anesthesia on the Radiosensitivity of Mice under Total Irradiation with X-Rays, Protons, and Carbon Ions

Autor:	V E, Balakin, O M, Rozanova, E N, Smirnova, T A, Belyakova, N S, Strelnikova
Rok vydání:	2022
Předmět:	Ions Xylazine Mice X-Rays Animals Anesthesia Dose-Response Relationship Radiation Protons Radiation Tolerance Carbon
Zdroj:	Doklady. Biochemistry and biophysicsREFERENCES. 506(1)
ISSN:	1608-3091
Popis:	The effect of xylazine-zoletyl anesthesia on the radiosensitivity of mice irradiated with protons, carbon ions in two regions of the Bragg curve, and X-ray radiation was studied according to the criteria of 30-day survival, dynamics of death, and the average life span of dead mice. The maximum effect of anesthesia by 3.3 times was observed by a decrease in the death of animals during irradiation with carbon ions at the Bragg peak; in the case of irradiation before the peak, the effect was 1.2 times. In the case of proton irradiation at the Bragg peak, the protective effect of anesthesia by a factor of 1.7 was observed only at a dose of 8.5 Gy. When mice were irradiated with X-rays in the dose range of 6.0-8.5 Gy, the anesthesia effect coefficient was 1.7-2. According to the 30-day survival method, it was shown that the use of a xylazine-zoletil mixture significantly changes the radiosensitivity of mice depending on the radiation dose and the radiation source quality.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::7b137d20ed7174ed6a456faf18c5ed8f https://pubmed.ncbi.nlm.nih.gov/36303049 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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