| Autor: |
Michelle N, Rheault, Heather, Bechtel, Joseph P, Neglia, Clifford E, Kashtan |
| Rok vydání: |
2010 |
| Předmět: |
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| Zdroj: |
Pediatric bloodcancer. 56(4) |
| ISSN: |
1545-5017 |
| Popis: |
Deferasirox (Exjade®, Novartis) is a widely used oral iron chelator for the treatment of patients with iron overload due to chronic transfusion therapy for diseases such as β-thalassemia and sickle cell disease. Renal side effects of deferasirox are common and include non-progressive increases in serum creatinine, however, the effect of deferasirox on proximal tubule function is unclear. We report one pediatric patient with reversible Fanconi syndrome associated with long-term deferasirox therapy and one patient with mild proximal tubular dysfunction. Kidney and proximal tubular function should be periodically monitored in patients receiving deferasirox throughout their course of therapy. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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