| Autor: |
C A, Penning, J K, Wright, J C, Ashby, J, Cunningham, N R, Rowell, P, Hughes |
| Rok vydání: |
1983 |
| Předmět: |
|
| Zdroj: |
Journal of clinicallaboratory immunology. 12(2) |
| ISSN: |
0141-2760 |
| Popis: |
Sera from 7 of 37 patients with systemic sclerosis (SS) were found to markedly enhance cytotoxicity in several established human target cell lines when co-cultured with normal human peripheral blood mononuclear cells (PBM). Fractionation studies indicated that the cytotoxicity-inducing activity resided in the IgG-containing fractions of serum and that the effector cells were Fc-receptor positive. By contrast, sera from 27 normal controls produced little or no cytotoxicity when co-cultured with the same target cell lines and normal PBM. Any slight enhancement of cytotoxicity that occurred with a single target cell line was, on fractionation, either labile or associated with albumin containing fractions. These findings raise the possibility that antibody-dependent cellular cytotoxicity (ADCC) could provide a pathogenetic mechanism in some patients with SS. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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