| Autor: |
Wusheng, Deng, Ke, Wang, Yun, Jiang, Dingbin, Li, Chongxi, Bao, Jing, Luo, Liuyuan, Liu, Bing, Huang, Jinliang, Kong |
| Rok vydání: |
2022 |
| Předmět: |
|
| Zdroj: |
BMJ open. 12(8) |
| ISSN: |
2044-6055 |
| Popis: |
Combination treatment with erlotinib plus bevacizumab has the potential to become a standard treatment regimen for patients with epidermal growth factor receptor mutation-positive (Systematic review and meta-analysis.The PubMed, Embase, Web of Science and Cochrane Library databases were searched, from inception to 15 January 2022.We included randomised controlled trials (RCTs), reported in English, assessing the efficacy of erlotinib plus bevacizumab versus erlotinib monotherapy in patients withThe main objective was to assess overall survival (OS), progression-free survival (PFS), objective response rate (ORR) and adverse events (AEs). Two independent reviewers extracted data and assessed the risk of bias. A random-effects model was used where there was evidence for homogeneous effects.Four RCTs (reported across six publications) were included in the meta-analysis, with a total of 775 patients included in the pooled analyses of PFS, OS and ORR (387 in the erlotinib plus bevacizumab intervention group and 388 in the erlotinib group). Compared with the erlotinib alone group, the erlotinib plus bevacizumab group achieved a significantly prolonged PFS (HR: 0.59; 95% CI 0.49 to 0.72; p0.00001; IErlotinib plus bevacizumab for the treatment of patients with |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
