Use of 6 M HCl for removal of the N-alpha-tert-butyloxycarbonyl group during solid-phase peptide synthesis

Autor:	H, Naharissoa, V, Sarrade, M, Follet, B, Calas
Rok vydání:	1992
Předmět:	Solutions Minerals Molecular Structure Formic Acid Esters Molecular Sequence Data Methods Amino Acid Sequence Hydrochloric Acid Sulfuric Acids Peptides Chromatography High Pressure Liquid
Zdroj:	Peptide research. 5(5)
ISSN:	1040-5704
Popis:	We describe the use of 6 M HCl to remove the Boc group in solid-phase peptide synthesis. Three peptides, 4-10 amino acid residues in length, have been successfully synthesized using 6 M HCl and were found to be comparable in purity to the same peptides prepared using the standard 50% trifluoroacetic acid in dichloromethane method of N-alpha-Boc removal.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::7ab71b116edba54e9709831e32085c99 https://pubmed.ncbi.nlm.nih.gov/1450524 Zobrazit plný text záznamu