| Autor: |
Anna M, Cabaj, Henryk, Majczyński, Erika, Couto, Phillip F, Gardiner, Katinka, Stecina, Urszula, Sławińska, Larry M, Jordan |
| Rok vydání: |
2016 |
| Předmět: |
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| Zdroj: |
The Journal of physiology. 595(1) |
| ISSN: |
1469-7793 |
| Popis: |
Experiments on neonatal rodent spinal cord showed that serotonin (5‐HT), acting via 5‐HT7 receptors, is required for initiation of locomotion and for controlling the action of interneurons responsible for inter‐ and intralimb coordination, but the importance of the 5‐HT system in adult locomotion is not clear.Blockade of spinal 5‐HT7 receptors interfered with voluntary locomotion in adult rats and fictive locomotion in paralysed decerebrate rats with no afferent feedback, consistent with a requirement for activation of descending 5‐HT neurons for production of locomotion.The direct control of coordinating interneurons by 5‐HT7 receptors observed in neonatal animals was not found during fictive locomotion, revealing a developmental shift from direct control of locomotor interneurons in neonates to control of afferent input from the moving limb in adults.An understanding of the afferents controlled by 5‐HT during locomotion is required for optimal use of rehabilitation therapies involving the use of serotonergic drugs. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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