| Autor: |
V U, Buko, F S, Larin, Iu A, Tarasov, V V, Vinogradov |
| Rok vydání: |
1983 |
| Předmět: |
|
| Zdroj: |
Ukrainskii biokhimicheskii zhurnal (1. 55(4) |
| ISSN: |
0201-8470 |
| Popis: |
The level of prostaglandins and 3':5'-AMP was studied in tissues of albino rats against a background of administering thiamine or its derivatives, oxythiamine and thiochrome. Oxythiamine (12.5 mg per 1 kg of mass; each 3 h for a day) increases the level of a sum of prostaglandins E and A as well as of prostaglandin F2 alpha in the liver and kidneys; thiochrome at the same dose produces the same effect for prostaglandins F and A in the liver and kidneys and for prostaglandin F2 alpha in the liver; and thiamine increases a sum of prostaglandins F and A in the kidneys. 72 h after a single injection of oxythiamine (40 mg per 100 g of mass) the level of prostaglandin E and A sum in the liver and kidneys increases as well, which is not connected with the effect of the substances under study on thiamine-dependent reactions. All the three compounds rise the 3':5'-AMP level in the liver. Variations in the prostaglandin content have no effect on the liver fatty acid composition. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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