Pentanoic acid induces thymic stromal lymphopoietin production through G

Autor:	Natsumi, Mizuno, Koudai, Abe, Yukari, Morishita, Saori, Yamashita, Ryosuke, Segawa, Jiangxu, Dong, Takahiro, Moriya, Masahiro, Hiratsuka, Noriyasu, Hirasawa
Rok vydání:	2017
Předmět:	Keratinocytes Mice Inbred BALB C rho-Associated Kinases Pyridines Amides Peptides Cyclic Mice Thymic Stromal Lymphopoietin Hypersensitivity Animals Cytokines GTP-Binding Protein alpha Subunits Gq-G11 Humans RNA Small Interfering Pentanoic Acids Cells Cultured Signal Transduction Skin
Zdroj:	International immunopharmacology. 50
ISSN:	1878-1705
Popis:	Thymic stromal lymphopoietin (TSLP) plays an important role in allergic skin inflammation. Short-chain fatty acids (SCFAs), including pentanoic acid, are products of bacterial metabolism and are associated with allergic skin disorders. However, whether SCFAs induce TSLP production is still unclear. In this study, we evaluated the effect of SCFAs on TSLP production and found that pentanoic acid was the most efficacious of the tested SCFAs. The G
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::7a2fa1c68f7424386cbe615fd77836cf https://pubmed.ncbi.nlm.nih.gov/28683366 Zobrazit plný text záznamu Full Text from ScienceDirect