| Autor: |
Leal, Raquel F, Milanski, Marciane, Ayrizono, Maria de Lourdes S, Coope, Andressa, Rodrigues, Viviane S, Portovedo, Mariana, Oliveira, Luiza M F, Fagundes, João J, Coy, Cláudio S R, Velloso, Lício A |
| Jazyk: |
angličtina |
| Rok vydání: |
2013 |
| Předmět: |
|
| Popis: |
Introduction: Crohn’s disease (CD) is a chronic intestinal ailment with a multifactorial etiology, whose incidence has increased during the last three decades. Recently, a role for mesenteric fat has been proposed in CD pathophysiology, since fat hypertrophy is detected nearby the affected intestinal area; however, there are few studies on this aspect. Aim: To evaluate inflammatory activity in intestinal mucosa and mesenteric fat tissue of patients with CD and controls. Materials and Methods: Ten patients with ileocecal CD and 16 patients with non-inflammatory disease (control groups) were studied. The specimens were snap-frozen and the expression of TLR-4, F4/80, IL1-β and IL-6 were determined by immunoblot of protein extracts. TLR4 RNA level were measured using RT-PCR. The t Test was applied (p |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
