| Autor: |
Genevieve M, Leyden, Michael P, Greenwood, Valérie, Gaborieau, Younghun, Han, Christopher I, Amos, Paul, Brennan, David, Murphy, George, Davey Smith, Tom G, Richardson |
| Rok vydání: |
2022 |
| Zdroj: |
British journal of cancer. |
| ISSN: |
1532-1827 |
| Popis: |
Body mass index (BMI) is known to influence the risk of various site-specific cancers, however, dissecting which subcomponents of this heterogenous risk factor are predominantly responsible for driving disease effects has proven difficult to establish. We have leveraged tissue-specific gene expression to separate the effects of distinct phenotypes underlying BMI on the risk of seven site-specific cancers.SNP-exposure estimates were weighted in a multivariable Mendelian randomisation analysis by their evidence for colocalization with subcutaneous adipose- and brain-tissue-derived gene expression using a recently developed methodology.Our results provide evidence that brain-tissue-derived BMI variants are predominantly responsible for driving the genetically predicted effect of BMI on lung cancer (OR: 1.17; 95% CI: 1.01-1.36; P = 0.03). Similar findings were identified when analysing cigarettes per day as an outcome (Beta = 0.44; 95% CI: 0.26-0.61; P = 1.62 × 10The study provides valuable insight into the divergent underlying pathways between BMI and the risk of site-specific cancers. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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