Association between lymphocyte subsets and cytomegalovirus infection status among patients with systemic lupus erythematosus
| Autor: | Qin, Ling, Qiu, Zhifeng, Hsieh, Evelyn, Geng, Taoran, Zhao, Jiuliang, Zeng, Xiaofeng, Wan, Lu, Xie, Jing, Ramendra, Rayoun, Routy, Jean Pierre, Li, Taisheng |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Adult
Male virus diseases Observational Study Pilot Projects Blood Sedimentation CD4+ T cells Lymphocyte Subsets systemic lupus erythematosus Case-Control Studies Lymphopenia Cytomegalovirus Infections Humans Lupus Erythematosus Systemic Female Lymphocyte Count Viremia CMV infection Research Article Retrospective Studies |
| Zdroj: | Medicine |
| ISSN: | 1536-5964 0025-7974 |
| Popis: | This study aimed to determine the association between different lymphocyte subsets and cytomegalovirus (CMV) infection status in patients with systemic lupus erythematosus (SLE). We performed a retrospective study among SLE patients with CMV infection and collected patient socio-demographic and clinical characteristics, as well as their recorded circulating lymphocyte subsets. Univariate and multivariable logistic regression analyses examined the relationship between CMV infection status and lymphocyte subset counts. We included 125 hospitalized patients with SLE, consisting of 88 with documented CMV infection and 37 without any evidence of CMV or other infections. Among the 88 CMV-infected patients, 65 (73.8%) patients developed CMV disease and 23 (26.2%) presented as CMV viremia. Compared to uninfected patients (1520 ± 101 cells/μL), lymphocytes remained stable among those with CMV viremia (1305 ± 272 cells/μL, P = .995). However, compared to their uninfected counterparts, there was a marked decrease in lymphocytes among patients with CMV disease (680 ± 513 cells/μL, P |
| Databáze: | OpenAIRE |
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