Enzymatic C-H activation of aromatic compounds through CO
| Autor: | Godwin A, Aleku, Annica, Saaret, Ruth T, Bradshaw-Allen, Sasha R, Derrington, Gabriel R, Titchiner, Irina, Gostimskaya, Deepankar, Gahloth, David A, Parker, Sam, Hay, David, Leys |
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| Rok vydání: | 2020 |
| Předmět: |
Models
Molecular Genomic Library Molecular Structure Carboxy-Lyases Carboxylic Acids Drug Evaluation Preclinical Carbon Dioxide Naphthalenes Decarboxylation Hydrocarbons Aromatic Enzyme Activation Structure-Activity Relationship Biodegradation Environmental Mutation Biocatalysis Amino Acid Sequence Oxidoreductases Styrene Benzofurans |
| Zdroj: | Nature chemical biology. 16(11) |
| ISSN: | 1552-4469 |
| Popis: | The direct C-H carboxylation of aromatic compounds is an attractive route to the corresponding carboxylic acids, but remains challenging under mild conditions. It has been proposed that the first step in anaerobic microbial degradation of recalcitrant aromatic compounds is a UbiD-mediated carboxylation. In this study, we use the UbiD enzyme ferulic acid decarboxylase (Fdc) in combination with a carboxylic acid reductase to create aromatic degradation-inspired cascade reactions, leading to efficient functionalization of styrene through CO |
| Databáze: | OpenAIRE |
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