| Autor: |
Danijela, Vucević, Natasa, Petronijević, Nevena, Radonjić, Aleksandra, Rasić-Marković, Dusan, Mladenović, Tatjana, Radosavljević, Dragan, Hrncić, Dragan, Djurić, Veselinka, Susić, Macut, Djuro, Olivera, Stanojlović |
| Rok vydání: |
2009 |
| Předmět: |
|
| Zdroj: |
General physiology and biophysics. |
| ISSN: |
0231-5882 |
| Popis: |
The aim of our study was to investigate the possible involvement of acetylcholinesterase (AchE) in mediating the early phase of acute lindane neurotoxicity in rats. Male Wistar rats (n = 48) were divided into following groups: 1. control, saline-treated group; 2. dimethylsulfoxidetreated group; 3. group that received lindane dissolved in dimethylsulfoxide, in a dose of 8 mg/kg intraperitoneally. Eight animals from each group were sacrificed 0.5 and 4 h after treatment and brain samples were prepared for further analysis. AchE activity (mitochondrial and synaptosomal fraction) was determined in cerebral cortex, thalamus, hippocampus and nc. caudatus spectrophotometrically. A significant increase in mitochondrial AchE activity was detected in cortex and nc. caudatus of lindane-treated animals 0.5 h after administration (p0.05). This rise was sustained in nc. caudatus within 4 h after treatment (p0.05). In contrast, activity of synaptosomal AchE fraction was significantly increased only in thalamus 4 h after lindane administration (p0.05). An increase in AchE activity may be involved in mediating acute neurotoxic effects of lindane, at least in some brain structures in rats. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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