Anabolic effects of progestogens in bone remodelling

Autor:	J J, Stĕpán, V, Schreiber
Rok vydání:	1995
Předmět:	Estradiol Norpregnenes Ovariectomy Alkaline Phosphatase Bone and Bones Hydroxyproline Bone Density Humans Osteoporosis Female Bone Remodeling Prospective Studies Norethindrone Progestins Follow-Up Studies
Zdroj:	Sbornik lekarsky. 96(4)
ISSN:	0036-5327
Popis:	The short-term effects of oestrogen deficiency on biochemical indices of bone turnover were studied in 49 women who had undergone hysterectomy with bilateral ovariectomy. In patients treated with norethisterone or tibolone, a significant reduction was observed in urinary hydroxyproline excretion comparable to that observed in estradiol treated patients. Bone isoenzyme of serum alkaline phosphatase activity did not decrease and bone mass remained increased during norethisterone and tibolone treatments. It is concluded that norethisterone and tibolone can act as bone-trophic hormones.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::79e5594e4993f2cf4906a75236ca9c80 https://pubmed.ncbi.nlm.nih.gov/8711371 Zobrazit plný text záznamu