New cytotoxic alkylated anthraquinone analogues from a soil actinomycete Streptomyces sp. WS-13394

Autor:	Zhao-Yuan, Wu, Wei, Fang, Li-Qiao, Shi, Zhong-Yi, Wan, Yong, Min, Kai-Mei, Wang
Rok vydání:	2014
Předmět:	Actinobacteria Inhibitory Concentration 50 Soil Alkylation Cell Line Tumor MCF-7 Cells Humans Anthraquinones Hep G2 Cells Drug Screening Assays Antitumor Streptomyces
Zdroj:	Chemicalpharmaceutical bulletin. 62(1)
ISSN:	1347-5223
Popis:	Four new alkylated anthraquinone analogues (1-4) were isolated from a soil actimomycete Streptomyces sp. WS-13394. The structures of compounds 1-4 were elucidated to be 1,4,6-trihydroxy-8-alkylanthraquinones by means of spectroscopic methods, including UV, one dimensional (1D), 2D-NMR and MS spectrometry. All compounds showed activities against BGC-823 and MCF-7 with IC50 from 0.99 to 3.54 µg/mL, while 2 exhibited cytotoxicity against HepG2, A875, BGC-823 and MCF-7 with IC50 2.29, 4.90, 0.99, and 1.66 µg/mL, respectively.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::79e4fb1ae9f2afcfe9a42ea4209b6298 https://pubmed.ncbi.nlm.nih.gov/24390501 Zobrazit plný text záznamu