[Novel prognostic marker in invasive breast cancer. ITIH5 expression is abrogated by aberrant promoter methylation]
| Autor: | J, Veeck, E, Breuer, M, Rose, M, Chorovicer, A, Naami, N, Bektas, S, Alkaya, S, von Serényi, F, Horn, A, Hartmann, R, Knüchel, E, Dahl |
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| Jazyk: | němčina |
| Rok vydání: | 2008 |
| Předmět: |
Reverse Transcriptase Polymerase Chain Reaction
Proteinase Inhibitory Proteins Secretory Breast Neoplasms DNA Methylation Prognosis Carcinoma Ductal Gene Expression Regulation Neoplastic Carcinoma Intraductal Noninfiltrating Phenotype Cell Line Tumor Biomarkers Tumor Disease Progression Humans Female Neoplasm Invasiveness Gene Silencing RNA Messenger Promoter Regions Genetic Follow-Up Studies Neoplasm Staging Oligonucleotide Array Sequence Analysis |
| Zdroj: | Der Pathologe. 29 |
| ISSN: | 1432-1963 |
| Popis: | We have recently characterized ITIH5 as a new extracellular matrix protein that exhibits clear expression loss in a variety of human tumour entities, including breast cancer. The aim of the present study was to decipher the molecular cause of ITIH5 expression loss in breast cancer and to learn more about the possible role of this molecule in cancer diseases. ITIH5 protein expression was found to be strongly reduced in 42% of invasive breast carcinomas-interestingly, with significant association with poor patient outcome. ITIH5 promoter methylation was frequently detected in breast cell lines and in primary carcinomas (40%), and it was functionally correlated with loss of ITIH5 mRNA expression. Moreover, ITIH5 promoter methylation was also significantly associated with poor clinical patient outcome and also with the occurrence of lymph node and distant metastases. In conclusion, we propose that ITIH5 may represent a novel metastasis repressor in human breast cancer. Both ITIH5 protein expression and ITIH5 promoter methylation may serve as prognostic biomarkers, thereby helping improve clinical patient outcome. |
| Databáze: | OpenAIRE |
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