Genetic and pharmacological antagonism of NK
| Autor: | A J, Sandweiss, M I, McIntosh, A, Moutal, R, Davidson-Knapp, J, Hu, A K, Giri, T, Yamamoto, V J, Hruby, R, Khanna, T M, Largent-Milnes, T W, Vanderah |
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| Rok vydání: | 2017 |
| Předmět: |
Male
Analgesics Mice Inbred ICR Morphine Dopamine Ventral Tegmental Area Receptors Opioid mu Receptors Neurokinin-1 Substance P Opioid-Related Disorders Acute Pain Nociceptive Pain Rats Sprague-Dawley Disease Models Animal Neurokinin-1 Receptor Antagonists Reward Gene Knockdown Techniques Receptors Opioid delta Escherichia coli Animals CRISPR-Cas Systems |
| Zdroj: | Molecular psychiatry. 23(8) |
| ISSN: | 1476-5578 |
| Popis: | Development of an efficacious, non-addicting analgesic has been challenging. Discovery of novel mechanisms underlying addiction may present a solution. Here we target the neurokinin system, which is involved in both pain and addiction. Morphine exerts its rewarding actions, at least in part, by inhibiting GABAergic input onto substance P (SP) neurons in the ventral tegmental area (VTA), subsequently increasing SP release onto dopaminergic neurons. Genome editing of the neurokinin 1 receptor (NK |
| Databáze: | OpenAIRE |
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