| Autor: |
P, Delagrange, R, Misslin, T W, Seale, B, Pfeiffer, S, Rault, P, Renard |
| Rok vydání: |
2001 |
| Předmět: |
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| Zdroj: |
Zhongguo yao li xue bao = Acta pharmacologica Sinica. 20(9) |
| ISSN: |
0253-9756 |
| Popis: |
To study the effect of S-21007, a 5-HT3 partial agonist in different animal models of anxiety in mice.S-21007 effects were evaluated in the behavior tests after intraperitoneal and oral acute treatment or in the light/dark test after both acute and chronic treatments.S-21007 presented anxiolytic-like properties after acute administration in the light/dark box test, the mirrored chamber test, and the elevated plus-maze at low doses 10 ng.kg(-1)-100 micrograms.kg-1, 1-100 micrograms.kg-1 and 10-100 micrograms.kg-1, respectively. In the light/dark box test, S-21007 was active orally after acute treatment at 100 ng.kg(-1)-10 mg.kg-1 and after chronic treatment (14 d) at 1-10 micrograms.kg-1. S-21007 was devoid of sedative or stimulatory effects.S-21007 exhibited anxiolytic-like properties. The mechanism of action may be a desensitization of 5-HT3 receptor or an antagonist activity on the 5-HT3 receptors. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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