[Study of peptide degradation in the serum by 1H-NMR]

Autor: O L, Isakova, N F, Sepetov, Zh D, Bespalova, V N, Bushuev, V A, Vinogradov
Rok vydání: 1986
Předmět:
Zdroj: Bioorganicheskaia khimiia. 12(1)
ISSN: 0132-3423
Popis: Enzymatic degradation of hexapeptide Tyr-D-Ala-Gly-Phe-Leu-Arg in human serum has been investigated by 1H-NMR spectroscopy, and its pathways are suggested. Its final degradation products, tetra- and pentapeptide, are shown to be stable in human serum for several hours. The NMR spectroscopy application for pharmacokinetic studies is substantiated.
Databáze: OpenAIRE