Comparative analysis of the structure and function of the chicken c-myc and v-myc genes: v-myc is a more potent inducer of cell proliferation and apoptosis than c-myc
| Autor: | C J, Petropoulos, I, Givol, S H, Hughes |
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| Rok vydání: | 1996 |
| Předmět: |
Oncogene Protein p55(v-myc)
Base Sequence Transcription Genetic Cell Cycle Genetic Vectors Molecular Sequence Data Genes myc Apoptosis Chick Embryo Sequence Analysis DNA Fibroblasts Gene Expression Regulation Neoplastic Cell Transformation Neoplastic Retroviridae Protein Biosynthesis Sequence Homology Nucleic Acid Animals Amino Acid Sequence Chickens Cell Division |
| Zdroj: | Oncogene. 12(12) |
| ISSN: | 0950-9232 |
| Popis: | To gain a more complete understanding of c-myc regulation in chickens, we have completed the structural characterization of the chicken c-myc gene and have begun to investigate c-myc transcription and protein expression. A comparison of c-myc structure and expression between mammals and birds presents an enigma: there are striking similarities in the pattern of gene expression in the absence of obvious sequence similarities in the controlling elements. We have begun to investigate c-myc and v-myc function using retroviral vectors that differ solely in the Myc proteins that they express. We show that while the overexpression of the smaller c-Myc protein is sufficient to induce morphological transformation in chicken embryo fibroblasts, overexpression of v-Myc provides a stronger signal for cells to enter the cell cycle and is a more potent inducer of apoptosis than c-Myc. |
| Databáze: | OpenAIRE |
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