Human beta defensin (HBD) gene copy number affects HBD2 protein levels: impact on cervical bactericidal immunity in pregnancy

Autor:	Catherine P, James, Mona, Bajaj-Elliott, Razan, Abujaber, Frida, Forya, Nigel, Klein, Anna L, David, Edward J, Hollox, Donald M, Peebles
Rok vydání:	2017
Předmět:	beta-Defensins DNA Copy Number Variations Pregnancy Uterus Gene Dosage Humans Female Pregnancy Complications Infectious Immunity Innate
Zdroj:	European journal of human genetics : EJHG. 26(3)
ISSN:	1476-5438
Popis:	Human beta defensin 2 (HBD2) is an endogenous mucosal antimicrobial peptide (AMP) upregulated during infection and inflammation. HBD2 is encoded by the DEFB4 gene, which exhibits extensive copy number variation. Previous studies have demonstrated a relationship between HBD copy number and serum HBD2 protein levels; however, our current understanding of the influence of copy number on mucosal AMP function remains limited. This study explores the relationship between HBD copy number, cervicovaginal HBD2 protein levels and antimicrobial activity in 203 women with risk factors for preterm birth. We provide evidence that suggests HBD copy number modulates cervical antimicrobial immunity.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::798b2dfef7b97e3d96034b1f9b819921 https://pubmed.ncbi.nlm.nih.gov/29367706 Zobrazit plný text záznamu Full text from SpringerLink