Evaluation of a special combination of glucan with organic selenium derivative in different murine tumor models
| Autor: | Vaclav, Vetvicka, Marcos Felipe, Pinatto-Botelho, Alcindo A, Dos Santos, Carlos A F, De Oliveira |
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| Rok vydání: | 2014 |
| Předmět: |
Mice
Inbred BALB C Antibodies Monoclonal Mammary Neoplasms Experimental Disaccharides Carcinoma Lewis Lung Mice Resveratrol Cell Line Tumor Organoselenium Compounds Antineoplastic Combined Chemotherapy Protocols Stilbenes Animals Humans Immunologic Factors Female Proteoglycans Cyclophosphamide Glucans Receptors Transforming Growth Factor beta |
| Zdroj: | Anticancer research. 34(12) |
| ISSN: | 1791-7530 |
| Popis: | β-glucans are well-established immunomodulators with strong effects resulting in slowing or even inhibiting cancer growth. Recent studies have repeatedly suggested that the biological activities of β-glucan can be potentiated by the addition of other bioactive agents. In the current study, we focused on the anticancer effects of a combination of yeast-derived β-glucan and a selenium-linked pseudodisaccharide. Using three different models of murine cancer, we showed that this combination strongly suppressed the growth of all three types of cancers, most likely via the interaction with natural anticancer antibodies. |
| Databáze: | OpenAIRE |
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