| Autor: |
F, Arias, J M, Otero, E, Londoño, H, Becerra, S, Carvajalino, C I, Rodríguez, J J, Granados, P, Quintero, M, Mora, C, Castro, H, Carranza, C, Vargas, A, Reyes, L, Rojas, L, Reveiz, A F, Cardona |
| Rok vydání: |
2011 |
| Předmět: |
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| Zdroj: |
Revista de gastroenterologia de Mexico. 77(2) |
| ISSN: |
0375-0906 |
| Popis: |
The procedure of radical peritonectomy followed by hyperthermic intraperitoneal chemotherapy (HIPEC) is considered the standard treatment for peritoneal cancers.To evaluate various outcomes in a cohort of patients with peritoneal tumors treated with HIPEC.Twenty-four patients consecutively treated with radical peritonectomy plus HIPEC within the time frame of November 2007 to July 2010 were enrolled; 15 (62%) had tumors of appendicular origin, 4 (16.7%) had primary peritoneal tumors, 2 had ovarian carcinomas and there was one case of colon cancer, one carcinosarcoma and one hemangioendothelioma. Mean age was 53 years (range: 26-68) and median follow-up was 14.2 months (range: 1-32). Demographic data, histology, peritoneal cancer index (PCI), surgical procedure characteristics, recurrence-free survival (RFS), and overall survival (OS) were all evaluated. Short-term morbidity and mortality were also determined.Complete cytoreduction was achieved in 18 patients (75%). Mean PCI was 15 (10: 41% and10: 58%), and the median (range) for surgery duration, length of stay in the Intensive Care Unit, parenteral nutritional support, and hospital stay were 12,5 (7-20) hours, 11,4 (2-74) days, 13,8 (12-65) days, and 29,1 (10-90) days, respectively. One patient (4%) died 6 months after the procedure, due to multiple associated complications. Considerable morbidity was seen in 52% of cases, including thromboembolic events (41%), catheter-related bacteremia (29%), fistulas (29%), and nephrotoxicity (25%). Six patients (25%) recurred after a median of 21 months of RFS.Cytoreductive surgery plus HIPEC in well-selected patients presenting with tumors that affect the peritoneum is a procedure that can be carried out in Colombia with an adequate safety and effectiveness profile. Mortality was similar to that reported in the international literature. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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