Autor:	Dario, Lehoux, Adel Rafai, Far, David, Kallend, Peter L J, Wijngaard, Brad, Zerler
Rok vydání:	2021
Předmět:	Male Macaca fascicularis Animals Female Asialoglycoprotein Receptor Cholesterol LDL RNA Small Interfering
Zdroj:	Toxicology and applied pharmacology. 443
ISSN:	1096-0333
Popis:	Inclisiran is a small interfering RNA molecule that was designed to reduce plasma low-density lipoprotein cholesterol (LDL-C) levels by inhibiting proprotein convertase subtilisin/kexin type 9 synthesis in the liver. This study aimed to characterize the tissue distribution and excretion of inclisiran after dosing in monkeys. A single 20 mg/kg subcutaneous injection of [
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::794012e0803140dba8a90d29e6cf5de0 https://pubmed.ncbi.nlm.nih.gov/35780943 Zobrazit plný text záznamu Full Text from ScienceDirect