Increase in CD5+ B cells in juvenile rheumatoid arthritis. Relationship to IgM rheumatoid factor expression and disease activity

Autor:	J N, Jarvis, J, Kaplan, N, Fine
Rok vydání:	1992
Předmět:	B-Lymphocytes Collagen Diseases Infant Enzyme-Linked Immunosorbent Assay CD5 Antigens Flow Cytometry Arthritis Juvenile Leukocyte Count Immunoglobulin M Antigens CD Rheumatoid Factor Child Preschool Humans Child
Zdroj:	Arthritis and rheumatism. 35(2)
ISSN:	0004-3591
Popis:	To investigate the association between CD5+ B cell expression and IgM rheumatoid factor (IgM-RF) in juvenile rheumatoid arthritis (JRA).CD5+ B cell levels analyzed by flow cytometry and IgM-RF expression determined by enzyme-linked immunosorbent assay were compared in children with JRA, children with other collagen vascular diseases, and healthy controls.Children with polyarticular JRA had expanded populations of CD5+ B cells, and expansion of CD5+ B cells and IgM-RF both correlated with disease activity.The results indicate that an expanded CD5+ B cell population leads to IgM-RF production in patients with polyarticular JRA, as well as patients with RA.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::7912fac5c077ea956610f7ff3cd2ed7f https://pubmed.ncbi.nlm.nih.gov/1370899 Zobrazit plný text záznamu Plný text