Novel Dicarboximide BK124.1 Breaks Multidrug Resistance and Shows Anticancer Efficacy in Chronic Myeloid Leukemia Preclinical Models and Patients' CD34

Autor: Iga, Stukan, Marek, Gryzik, Grażyna, Hoser, Andrew, Want, Wioleta, Grabowska-Pyrzewicz, Mikolaj, Zdioruk, Mariola, Napiórkowska, Marcin, Cieślak, Karolina, Królewska-Golińska, Barbara, Nawrot, Grzegorz, Basak, Urszula, Wojda
Rok vydání: 2022
Zdroj: Cancers. 14(15)
ISSN: 2072-6694
Popis: The search is ongoing for new anticancer therapeutics that would overcome resistance to chemotherapy. This includes chronic myeloid leukemia, particularly suitable for the studies of novel anticancer compounds due to its homogenous and well-known genetic background. Here we show anticancer efficacy of novel dicarboximide denoted BK124.1 (C
Databáze: OpenAIRE