Simultaneous pancreas-kidney transplantation at the University of Pittsburgh
| Autor: | R, Shapiro, M L, Jordan, V P, Scantlebury, C A, Vivas, A, Jain, P, Chakrabarti, J, McCauley, J, Johnston, P, Randhawa, A, Rao, J J, Fung, R J, Corry |
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| Rok vydání: | 2000 |
| Předmět: |
Adult
Graft Rejection Immunosuppression Therapy Time Factors Graft Survival Middle Aged Pennsylvania Kidney Transplantation Tacrolimus Hospitals University Survival Rate Diabetes Mellitus Type 1 Cause of Death Humans Kidney Failure Chronic Diabetic Nephropathies Drug Therapy Combination Pancreas Transplantation Immunosuppressive Agents Bone Marrow Transplantation Retrospective Studies |
| Zdroj: | Clinical transplants. |
| ISSN: | 0890-9016 |
| Popis: | Analysis of the SPK program at the University of Pittsburgh has led to a number of observations: 1. Under tacrolimus-based immunosuppression, without antibody induction, it has been possible to achieve (a) One- and 3-year actuarial patient survival rates of 98% and 95% (b) One- and 3-year actuarial kidney survival rates of 95% and 87% (c) One- and 3-year actuarial pancreas survival rates of 86% and 80% 2. Steroid withdrawal has been achieved in over half of the successfully transplanted recipients, with excellent outcomes and a low rate (4.7%) of subsequent rejection. 3. Bone marrow augmentation has been associated with (a) less rejection (b) less pancreatic graft loss to rejection (c) an increased ability to withdraw steroids 4. Rejection has been associated with a rising serum lipase. 5. Renal allograft rejection in SPK patients with elevated serum lipase levels has been seen in the setting of normal renal function. 6. Enteric drainage has been associated with a reasonably low complication rate. 7. SPK transplantation is a successful therapeutic option in selected type I diabetics with end-stage renal disease. |
| Databáze: | OpenAIRE |
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