| Autor: |
Diana Rodica, Tudoraşcu, Daniel, Pirici, Elena Anca, Târtea, Edme Roxana, Mustafa, Cristina, Florescu, Cristin Constantin, Vere, Alina Maria, Balea, Ileana, Puiu, Georgică Costinel, Târtea, Valeria Carmen, Albu |
| Rok vydání: |
2018 |
| Předmět: |
|
| Zdroj: |
Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie. 58(4) |
| ISSN: |
2066-8279 |
| Popis: |
The aim of this study is to assess the status of synapses in normal colorectal tissue compared to neoplastic colorectal tissue, and to correlate this status with survival in patients with colorectal neoplasia. Our study included 61 patients diagnosed with colorectal adenocarcinoma, representing the study group, and 53 patients diagnosed with benign conditions, that required a resection of a colorectal segment, representing the control group. We performed the immunohistochemical staining by using anti-synaptophysin antibody, which identifies synaptic vesicles and, so, we managed to analyze the expression of synapses in colorectal adenocarcinoma. Regarding both the signal area and integrated optical density (IOD) of the synaptophysin, the univariate analysis with a log-rank (Mantel-Cox) test indicated that patients with a low level of synaptophysin had a better overall survival rate than those with a high-level synaptophysin. Also, we noticed that tumor size, tumor invasion and lymph node metastasis were significantly associated with the overall survival rate, whereas the other clinicopathological features were not. In conclusion, the status of synaptic vesicles evaluated via synaptophysin expression in patients with colorectal cancer positively correlates with the survival rate and it can play a role in the neoplastic therapy process. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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