| Autor: |
Shao-Hua, Chen, Xiang-Feng, Zha, Yang-Qiu, Li |
| Rok vydání: |
2016 |
| Předmět: |
|
| Zdroj: |
Zhongguo shi yan xue ye xue za zhi. 24(5) |
| ISSN: |
1009-2137 |
| Popis: |
The main mechanism of tumor immune suppression is due to the T cell exhaustion which is mediated by abnormal expression of T-cell immunosuppressive receptors in immune cells. Blocking these molecules may restore partial or all functions of T cells. This article reviews the advance on the role of the newly discovered T cell immuno-suppressive receptors such as TIM-3, LAG-3 and BTLA, including their mediated T cell-immune tolerance and the study of targeted immunotherapy in hematological malignancies, so as to provide the new strategy for immune-targeted therapy for hematological malignancies. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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