Rhabdomyosarcoma of the prostate--report of a case with an immunohistochemical study of the neoplastic rhabdomyoblast

Autor: H, Tamauchi, Y, Tsutsumi, T, Nishino, K, Katoh, Y, Osamura, J, Hata, Y, Nagata, N, Kawamura, N, Tamaoki
Rok vydání: 1984
Předmět:
Zdroj: The Tokai journal of experimental and clinical medicine. 9(4)
ISSN: 0385-0005
Popis: A case of rhabdomyosarcoma of the embryonal alveolar type arising from the prostate in a 6-year-old boy was reported with a immunohistochemical survey. Tumor cells in the biopsied inguinal lymph node were weakly positive for myoglobin and CPK-mm and showed positive staining for neuron specific enolase (NSE). At autopsy, an immunohistochemical examination demonstrated that the tumor cells, especially differentiated elongated cells, were strongly positive for myoglobin, CPK-mm and NSE. An enzyme immunoassay for three distinct subunits of NSE revealed a 320 fold increase in the beta subunit of enolase which is specific for heart and skeletal muscle. The diagnostic significance of immunohistochemical methods for rhabdomyoblasts was discussed.
Databáze: OpenAIRE