Correction of fasting hyperglycaemia with insulin or sulphonylurea lowers fasting ketone levels, but does not alter resting or post-glucose energy expenditure in non insulin dependent diabetes. Differences between the OGTT and the glucose clamp

Autor:	K, Boyd, C, Boreham, W J, Andrews, D R, Hadden
Rok vydání:	1991
Předmět:	Blood Glucose Male C-Peptide Fasting Ketone Bodies Glucose Tolerance Test Middle Aged Glucose Diabetes Mellitus Type 2 Liver Hyperglycemia Glyburide Glucose Clamp Technique Humans Insulin Female Energy Metabolism
Zdroj:	Diabetes research (Edinburgh, Scotland). 18(3)
ISSN:	0265-5985
Popis:	Sixteen non-obese non insulin dependent diabetic patients had a 75 g oral glucose tolerance test with simultaneous measurement of intermediary metabolites and of overall energy expenditure by indirect calorimetry during the test. The same patients had a 3H3 glucose infusion and hyperinsulinaemic glucose clamp procedure with glucose held at 10.0 mmol/l and insulin infused at 40 mU/m2/min. The changes in glucose and fat metabolism, in total energy balance and the fall in RQ during the glucose tolerance test did not correlate with the measures of hepatic glucose output or peripheral insulin resistance in these patients. Although the concept of insulin resistance is useful in considering the non insulin dependent diabetic state, the data derived from the body responses to a single glucose load are more relevant to the day to day fluctuation of the internal environment.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::7856f21de0b69574decea98b751f5d73 https://pubmed.ncbi.nlm.nih.gov/1841819 Zobrazit plný text záznamu