[Effectiveness of tocopherol and anti-hypoxic agents in liver damage caused by antitubercular agents]

Autor:	N P, Skakun, Iu I, Slivka
Rok vydání:	1991
Předmět:	Male Disease Models Animal Isoniazid Animals Vitamin E Chemical and Drug Induced Liver Injury Hepatitis Animal Rifampin Inosine Diphosphate Piracetam Pyrazinamide Antioxidants Rats
Zdroj:	Problemy tuberkuleza. (3)
ISSN:	0032-9533
Popis:	Two-week administration of isoniazid, rifampicin (50 mg/kg and pyrazinamide (1,5 g/kg) to white rats brings about liver affection characterized by a higher activity of alanine and aspartate aminotransferases, lipid peroxidation activation and bile production inhibition. With the liver affected by antituberculous drugs, protective action is provided by acetate tocopherol an antioxidant, and piracetam riboxin and pyriditol, antihypoxic agents.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::785172c5e6fdd388d2643e73f68aac0b https://pubmed.ncbi.nlm.nih.gov/1871097 Zobrazit plný text záznamu