Efficacy of L-627, a new carbapenem, in the treatment of experimentally induced intra-abdominal infections in rats
| Autor: | C E, Nord, G, Lahnborg |
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| Rok vydání: | 1992 |
| Předmět: | |
| Zdroj: | Drugs under experimental and clinical research. 18(10) |
| ISSN: | 0378-6501 |
| Popis: | A reproducible experimental model of intra-abdominal infections in rats has been devised in order to simulate intra-abdominal sepsis in patients. Pre-operatively, the rats were fed lean ground beef for two weeks in order to change the intestinal flora to one similar to that of humans. A 1-cm segment of ileum was isolated on its vascular pedicle. The intestine was then divided at each end of the segment and intestinal continuity was re-established by an end-to-end anastomosis. The segment of ileum was then returned to the abdominal cavity. This experimental model was used to compare the efficacy of L-627 with the combination of gentamicin plus metronidazole. Eighty per cent of the untreated animals died within three days. Animals treated with L-627 or gentamicin plus metronidazole had significantly decreased mortality and increased cure rates during the experimental period. Only two animals in the two treatment groups died. L-627 seems to be as useful as gentamicin plus metronidazole in the treatment of intra-abdominal infections. |
| Databáze: | OpenAIRE |
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